Progesterone could reduce the risk of miscarriage in early pregnancy bleeding

Research led by the University of Birmingham suggests that giving progesterone to pregnant women with early pregnancy bleeding and a history of miscarriage could increase their chances of having a baby. The PRISM trial, funded by the National Institute for Health Research (NIHR) and coordinated by Birmingham Clinical Trials Unit in collaboration with Tommy’s National Centre for Miscarriage Research, is the largest ever trial of its kind and involved 4,153 pregnant women who presented with early pregnancy bleeding. The women, being treated at 48 hospitals across the UK and with the average age of 31, were randomly assigned by computer into one of two groups