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The connection between NETs and sepsis: the potential for new diagnostic tools and treatments

This article explores the connection between neutrophil extracellular traps (NETs) and sepsis, and how this discovery could pave the way for new diagnostic tools and treatments.

Every year, there are roughly 50 million cases of sepsis worldwide, with one in five (11 million) dying from the disease annually.1 Sepsis is more common than heart disease, stroke and cancer, and is a leading cause of death in hospitals, yet it is significantly underfunded compared to these other disease areas. Each year, the US spends $2,277m on cancer research, $1,236m on heart disease and $317m on stroke care, but just $91m on sepsis (Figure 1). Figure 1. Source: Djillali Annane (2023) A lack of funding in sepsis research has meant there is currently no therapeutic, individualised treatment for


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