Management of metastatic bone disease

Metastatic bone disease is a common cause of pain and disability for patients with advanced cancer. Early detection and appropriate management can limit pain, reduce disability and prevent complications such as hypercalcaemia, pathological fracture and spinal cord compression. In specific cases surgical resection of an isolated bone metastasis may improve survival. This article provides an evidence-based overview of the investigation and management of patients with metastatic bone disease.