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Macrolides antibiotics should be used with caution in pregnancy

Macrolide antibiotics used during early pregnancy increase the risk of major birth defects, particularly heart defects, compared with children of mothers prescribed penicillin, according to a new study which advises that alternative antibiotics should be prescribed until further research is available.

Macrolide antibiotics used during early pregnancy increase the risk of major birth defects, particularly heart defects, compared with children of mothers prescribed penicillin, according to a new study which advises that alternative antibiotics should be prescribed until further research is available. The study published in The BMJ assessed the association between macrolide antibiotics prescribed during pregnancy and major malformations as well as four neurodevelopmental disorders (cerebral palsy, epilepsy, ADHD, and autism spectrum disorder) in children. Macrolide antibiotics (including erythromycin, clarithromycin, and azithromycin) are €“ widely used to treat common bacterial infections. They are often used as alternatives for patients with penicillin allergy. It analysed data from

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