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Hearing aids could reduce cognitive decline in older adults

Treating hearing loss with hearing aids could protect against cognitive decline in older adults at greater risk of dementia, according to new research in the Lancet.

Treating hearing loss with hearing aids could protect against cognitive decline in older adults at greater risk of dementia, according to new research in the Lancet.

The study, which was the first randomised controlled trial (RCT) of its kind, was presented at the Alzheimer’s Association International Conference (AAIC).

It adds to the growing evidence that addressing hearing impairment may be a critically important global public health target for dementia prevention efforts. It was estimated by the 2020 Lancet Commission on Dementia to contribute to around 8% of dementia cases worldwide—equivalent to 800,000 of the nearly 10 million new cases of dementia diagnosed every year.

Age-related hearing loss is extremely common, affecting two-thirds of adults aged over 60 globally, but less than one in 10 individuals with hearing loss in low- and middle-income countries, and fewer than three in 10 in high-income countries, currently use hearing aids.

Professor Frank Lin of Johns Hopkins University School of Medicine and Bloomberg School of Public Health, said: “These results provide compelling evidence that treating hearing loss is a powerful tool to protect cognitive function in later life, and possibly, over the long term, delay a dementia diagnosis. But any cognitive benefits of treating age-related hearing loss are likely to vary depending on an individuals’ risk of cognitive decline.”

Hearing aids could really make a difference for populations at risk of dementia

The ACHIEVE randomised trial included 977 adults aged 70–84 years with untreated hearing loss who were free from substantial cognitive impairment in four communities across the USA.

Participants were recruited from two populations at each site: older adults participating in a longstanding observational study of cardiovascular health (Atherosclerosis Risk in Communities [ARIC] study, and new volunteers from the same communities who were generally healthier than participants from ARIC.

Participants were randomised to either a hearing intervention (audiological counselling and hearing aids) or the control intervention involving more generalised counselling on healthy ageing (individual sessions with a health educator covering topics on chronic disease and disability prevention), and were followed-up twice a year over three years.

The primary analysis of the results, combining both the ARIC and volunteer cohorts, found that the hearing intervention did not reduce cognitive decline over time—with no significant difference in cognitive change between those receiving the hearing intervention and the health education control over three years (-0.200 vs -0.202 standard deviation units).

The researchers also did a sensitivity analysis (pre-specified in the trial design) to examine the effect of the hearing intervention within the ARIC cohort (who are at greater risk of cognitive decline) and the healthy volunteers.

In the ARIC cohort, three-year cognitive change was 48% lower in the hearing intervention group than the control group (-0.211 vs -0.402 standard deviation units).

Hearing loss can make the brain work harder to the detriment of other mental functions like thinking and memory. Another possibility is that hearing loss causes the ageing brain to shrink more quickly. A third possibility is that hearing loss leads people to be less socially engaged and the reduced stimulation may result in brain atrophy.

While previous observational research suggests that treating hearing loss may protect against cognitive decline and dementia, these studies may be biased because individuals who have the means and choose to get their hearing loss treated may be healthier and at lower risk of cognitive decline than those who don’t. As a result, the effectiveness of hearing aid use on reducing cognitive decline in cognitively-healthy older adults with hearing loss remained unclear.

Benefit in patients with risk factors for cognitive decline

Professor Lin added: “Although our primary analysis of the combined ARIC and health volunteer cohorts did not find a difference in cognitive decline for those using hearing aids, when we did sensitivity analyses to test its robustness there was clear evidence indicating a significant benefit for older adults in the ARIC cohort who had more risk factors for cognitive decline.

“Despite similar levels of hearing at the start of the study, it’s likely that volunteers in the healthier cohort experienced slower rates of cognitive change than ARIC participants because they tended to be younger, had fewer risk factors for cognitive decline, and had better initial cognitive scores. This much slower rate of cognitive decline may have limited any effect of hearing aids in further reducing this decline over the relatively short 3-year follow-up.”

The study provides the first RCT-level evidence to support treating hearing loss to reduce cognitive decline in older at-risk adults, confirming conclusions by the 2020 Lancet Commission on Dementia and the 2022 United States National Plan to Address Alzheimer’s Disease that called for treating age-related hearing loss to supplement existing national dementia risk reduction strategies.

Despite the important findings, the authors note some limitations including that participants and researchers could not be masked to the intervention, which could potentially bias the results, and that two of the 10 neurocognitive tests contained only auditory stimuli, so individuals receiving the health education control with untreated hearing loss could potentially perform more poorly on these tests.

Writing in a linked Comment, Professor Gill Livingston from University College London, UK (who was not involved in the study) says, “We also need long-term follow-up of ACHIEVE to see if  the hearing intervention results in cognitive differences over time, particularly in healthy volunteers. Finally, we urgently need more trials in other settings, using the lessons learnt about the need to focus on purposively sampled populations at high risk of cognitive decline
and dementia. Overall, the findings from this study are hopeful. Hearing aids could really make a difference for populations at risk of dementia.”

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